Estoril (II) – Boavista (I) – 2-1
Fontinhas – Fafe – 1-1 (1-1 a.p.) (3-4 g.p.)
Sporting (I) – Paços de Ferreira (I) – 3-0
Montijo – Sp. Braga (I) – 0-7 (14.12.2020)
Nacional (I) – Leixões (II) – 3-1 (23.12.2020)
Benfica (I) – Vilafranquense (II) – 5-0
B SAD (I) – Sp. Espinho – 0-0 (3-0 a.p.) (23.12.2020)
Anadia – C. F. Estrela Amadora – 0-1 (14.12.2020)
Rio Ave (I) – Famalicão (I) – 2-1
U. Leiria – Gil Vicente (I) – 0-3 (23.12.2020)
FC Porto (I) – Tondela (I) – 2-1
Marítimo (I) – Salgueiros – 1-1 (2-1 a.p.) (23.12.2020)
V. Guimarães (I) – Santa Clara (I) – 0-1
Ac. Viseu (II) – Académica (II) – 3-0
Torreense – Amora – 1-0 (14.12.2020)
Cova Piedade (II) – Moreirense (I) – 1-1 (2-3 a.p.)